An improved process of lactonization in the preparation of statins

• Main Authors: THAPER, RAJEST KUMAR, KUMAR, S.M. DILEEP, KUMAR, YATENDRA, KHANNA, JAG MOHAN
• Format: Patent
• Language: English; French; German
• Published: 21.04.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

An improved process of lactonization in the preparation of statins (e.g., the HMG-CoA reductase inhibitors lovastatin and simvastatin) employs very mild reaction conditions. The improved process comprises treating the open ring hydroxy acid form of the statins with an excess of acetic acid and in th...