DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS

• Main Authors: RAMIREZ-WEINHOUSE, MICHELLE, KATAOKA, KENICHIRO, TARBY, CHRISTINE, TANAKA, HIROKO, MOREE, WILNA, SHIOTA, TATSUKI, BARNUM, DOUG, YAMAGAMI, SHINSUKE, GREENE, JONATHAN, ENDO, NORIAKI
• Format: Patent
• Language: English; French; German
• Published: 21.11.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Cyclic diamines of formula (I) or their pharmacologically acceptable acid addition salts, and their medical applications are described. These compounds inhibit the action of chemokines such as MIP-1a and/or MCP-1 on target cells, and are useful as a therapeutic drug and/or preventative drug in disea...