IRREVERSIBLE INHIBITORS OF TYROSINE KINASES

The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the tr...

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Bibliographic Details
Main Authors DENNY, WILLIAM ALEXANDER, SHOWALTER, HOWARD, DANIEL, HOLLIS, DOHERTY, ANNETTE, MARIAN, FRY, DAVID, W, MCNAMARA, DENNIS, JOSEPH, DOBRUSIN, ELLEN, MYRA, BRIDGES, ALEXANDER, JAMES, SMAILL, JEFFREY B, ZHOU, HAIRONG
Format Patent
LanguageEnglish
French
German
Published 18.11.2009
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.
Bibliography:Application Number: EP19970920213