PYRIDINECARBOXAMIDE DERIVATIVES

• Main Authors: NISHIMURA, KAZUMI, SAKAI, HIROSHI, MURAKI, YUKIKO, OSHIDA, NORIO, YOKOYAMA, SHINJI, ITOH, KOICHI, SAKURAI, EINOSUKE, SATOH, HIROAKI, TONOIKE, TOMOMI, MIMAKI, YOJI, HAMADA, TAMIKO, SUGAI, TOSHIJI
• Format: Patent
• Language: English; French; German
• Published: 02.02.2000
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

N-(12-Nitroxydodecyl)-6-(4-ethyl or isopropyl-1-piperazinyl)pyridine-3-carboxamide or physiologically acceptable salts thereof. The said compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed neuronal death (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage cerebrovascular disorders and then the compounds are useful as an inhibiting agent for cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, because the compounds do hardly show a behavior suppressing action, which is considered to be side effect in treating cerebrovascular disorders at the acute stage, they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders. Moreover, the compounds show a cerebral protective activity (an anti-anoxic activity), an activity of increasing cerebral blood flow, and an activity of inhibiting lipid peroxidation, and these activities may lead to the increased utility as a therapeutic agent for cerebrovascular disorders.