CYTOPLASMIC MODULATORS OF INTEGRIN REGULATION/SIGNALING
The present invention provides purified and isolated polynucleotides encoding IRP polypeptides which regulate beta2 and beta7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities an...
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Main Authors | , |
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Format | Patent |
Language | English French German |
Published |
08.04.1998
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Abstract | The present invention provides purified and isolated polynucleotides encoding IRP polypeptides which regulate beta2 and beta7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes. |
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AbstractList | The present invention provides purified and isolated polynucleotides encoding IRP polypeptides which regulate beta2 and beta7 integrins and which are contemplated to participate in integrin signaling and/or recycling pathways. Also provided are methods for identifying modulators of IRP activities and methods for identifying other proteins which interact with IRP polypeptides in signaling pathways. Modulators of IRP interactions are contemplated to be useful, for example, in monitoring and treating inflammatory processes involving leukocytes. |
Author | LIPSKY, BRIAN, P STAUNTON, DONALD, E |
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DocumentTitleAlternate | MODULATEURS CYTOPLASMIQUES DE LA REGULATION/SIGNALISATION DE L'INTEGRINE CYTOPLASMATISCHE REGULATOREN DER INTEGRINREGULATION UND -SIGNALÜBERTRAGUNG |
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Snippet | The present invention provides purified and isolated polynucleotides encoding IRP polypeptides which regulate beta2 and beta7 integrins and which are... |
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Title | CYTOPLASMIC MODULATORS OF INTEGRIN REGULATION/SIGNALING |
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