2,3-Cyclic condensed 1,4-dihydropyridines, process for their preparation and their use as K-channel modulators

• Main Authors: JUNGE, BODO, DE VRY, JEAN-MARIE-VIKTOR, SOMMERMEYER, HENNING, URBAHNS, KLAUS, HEINE, HANS-GEORG, SCHOHE-LOOP, RUDOLF, WITTKA, REILINDE, GLASER, THOMAS, GOLDMANN, SIEGFRIED
• Format: Patent
• Language: English; French; German
• Published: 10.04.1996
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Die vorliegende Erfindung betrifft neue 2,3-cyclisch kondensierte 1,4-Dihydropyridine der allgemeinen Formel (I), in welcher R, R¹, R², D und E die in der Beschreibung angegebene Bedeutung haben, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel, vorzugsweise zur Behandlung des zentralen Nervensystems. 2,3-Fused 1,4-dihydropyridine-5-carboxylic acid derivs. of formula (I) and their salts are new: R = 6-10C aryl or pyridyl, opt. substd. by 1-5 of CN, halogen, CF3 and 1-6C alkylthio; R1 = H or 1-8C alkyl; R2 = 1-6C alkyl or 3-6C cycloalkyl; D+E = -CO-(CH2)3-, -CO-CH2-CMe2-CH2-, -CO-O-CH2- or -CH2-O-CO-.