Benz[e]indene derivatives and a process for preparing them as well as medicaments containing them and the use of them

• Main Authors: SIMIG, GYULA, REITER NEE ESZES, KLARA, BUDAI, ZOLTAN, BLASKO, GABOR, MEZEI, TIBOR, GYERTYAN, ISTVAN DR
• Format: Patent
• Language: English; French; German
• Published: 24.07.1996
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A subject-matter of the invention are benz[e]indene derivatives of the generel formula wherein A represents a group of the formula in which latter alk means a C2-7 alkylene group, optionally substituted by a hydroxy group and R1 and R2 stand independently for hydrogen or a C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C3-7 cycloalkyl, mono-(C1-7)alkylamino-(C1-7)alkyl or di-(C1-7)alkylamino-(C1-7)alkyl group or R1 and R2 together with the nitrogen atom to which they are attached form a 4 to 7 membered heterocyclic ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may be substituted by a phenyl, benzyl, pyridyl, pyrimidinyl or C1-3 alkyl group which latter ones, in turn, may be substituted by a hydroxy or methoxy group or a halogen atom or a halophenyl group or R1 and R2 together with the nitrogen atom to which they are attached form a phthalimido group or A means a pyrimidino group, a 2,3-(epoxy)-propyl group or a group of the formula in which latter R3 stands for a C1-7 alkyl, C2-7 alkenyl or C3-8 cycloalkyl group and R denotes hydrogen or a C1-7 alkyl group, and their stereoisomers and optically active isomers and mixtures thereof, as well as acid addition salts and quaternary ammonium derivatives of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds.