Alkyl avermectin derivatives
There are disclosed avermectin derivatives with a hydroxy and hydrocarbon substituents at the 5, 10, 13, 23, 4 min and 4 sec positions which are prepared by the reaction of the 5, 10, 13, 23, 4 min or 4 sec ketone compound with an organo-metallic Grignard reagent. The compounds are potent antiparasi...
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Main Authors | , , |
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Format | Patent |
Language | English French German |
Published |
20.12.1995
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Edition | 5 |
Subjects | |
Online Access | Get full text |
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Abstract | There are disclosed avermectin derivatives with a hydroxy and hydrocarbon substituents at the 5, 10, 13, 23, 4 min and 4 sec positions which are prepared by the reaction of the 5, 10, 13, 23, 4 min or 4 sec ketone compound with an organo-metallic Grignard reagent. The compounds are potent antiparasitic and anthelmintic agents in human and animal therapy and are potent pesticidical agents against agricultural pests. Compositions containing such compounds as the active agent are also disclosed. |
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AbstractList | There are disclosed avermectin derivatives with a hydroxy and hydrocarbon substituents at the 5, 10, 13, 23, 4 min and 4 sec positions which are prepared by the reaction of the 5, 10, 13, 23, 4 min or 4 sec ketone compound with an organo-metallic Grignard reagent. The compounds are potent antiparasitic and anthelmintic agents in human and animal therapy and are potent pesticidical agents against agricultural pests. Compositions containing such compounds as the active agent are also disclosed. |
Author | SHIN, THOMAS L MROZIK, HELMMUT ESKOLA, PHILIP |
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Discipline | Medicine Chemistry Sciences Forestry Agriculture |
DocumentTitleAlternate | Alkylavermectin-Derivate Dérivés d'alkyl avermectine |
Edition | 5 |
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RelatedCompanies | MERCK & CO. INC |
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Snippet | There are disclosed avermectin derivatives with a hydroxy and hydrocarbon substituents at the 5, 10, 13, 23, 4 min and 4 sec positions which are prepared by... |
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SubjectTerms | AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY DERIVATIVES THEREOF FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS TRAPPING |
Title | Alkyl avermectin derivatives |
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