PROCESS FOR THE PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF VITAMIN-D3 METABOLITES, AND INTERMEDIATES
The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 2...
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| Main Authors | , , |
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| Format | Patent |
| Language | English German |
| Published |
18.08.1982
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D3 metabolites. |
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| AbstractList | The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and 24R,25-dihydroxycholecalciferol from 17-keto steroids via intermediates having the natural steroid configuration at the 20-position. These novel intermediates are prepared from 17-keto steroids by reaction with ethyltriphenylphosphonium halides followed by reaction with formaldehyde to form comounds having the natural steroid configuration at the 20-position and which are suitable substrates for the preparation of the aforementioned Vitamin D3 metabolites. |
| Author | USKOKOVIC, MILAN R BATCHO, ANDREW D BERGER, DONALD E. JR |
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| Notes | Application Number: EP19810108386 |
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| PublicationDateYYYYMMDD | 1982-08-18 |
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| PublicationDecade | 1980 |
| PublicationYear | 1982 |
| RelatedCompanies | F. HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT |
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| Snippet | The present disclosure is directed to a process and intermediates for the synthesis of Vitamin D3 metabolites such as 1,25-dihydroxycholecalciferol,... |
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| SubjectTerms | CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS |
| Title | PROCESS FOR THE PREPARATION OF INTERMEDIATES IN THE SYNTHESIS OF VITAMIN-D3 METABOLITES, AND INTERMEDIATES |
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