TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASES

• Main Authors: TIKHE, JAYASHREE, WEBBER, STEPHEN, EVAN, THORENSEN, LARS, HENRIK, CANAN-KOCH, STACIE, S
• Format: Patent
• Language: English; Russian
• Published: 28.10.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

1. A compound of general formula (I) capable to inhibit poly (ADP-ribose) polymerase (PARP): wherein: R is halogen; cyano group; an optionally substituted (C1-C10) alkyl, (C2-C10) alkenyl, (C2-C10) alkynyl, (C3-C18) cycloalkyl, heterocycloalkyl having 3-18 atoms, comprising from 1 to 5 N, O or S ato...