KRYSTALLINE FORMER AF 2-[(2S)-1-AZABICYCLO[2.2.2]OCT-2-YL]-6-(3-METHYL-1H-PYRAZOL-4-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ON HEMI-HYDRAT

• Main Authors: IWATA, Kentaro, YASUMA, Tsuneo, Zhu, Lei, HOMMA, Misaki, BAILEY, John, Daniel, MAEDA, Kazuhiro, OGURO, Yuya, PATIL, Siddhesh, Dinanath, TAYA, Naohiro, LANGSTON, Marianne, MIZUNO, Masahiro, ROY, Lilly, GOUR, Shruti
• Format: Patent
• Language: Danish
• Published: 30.08.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to crystalline forms of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one hemihydrate (Compound 1) and/or tautomers thereof, wherein Compound 1 has the structure: (I)·0.5H2O; processes for preparing crystalline forms of C...