RETINOID-LIPOSOMER TIL FORBEDRING AF MODULERING AF HSP47-EKSPRESSION

• Main Authors: AVKIN-NACHUM, Sharon, NIITSU, Yoshiro, AHMADIAN, Mohammad, PERELMAN, Loren A, YING, Wenbin, LUI, Yun, PAYNE, Joseph E, KNOPOV, Victor, TANAKA, Yasunobu, FEINSTEIN, Elena, WITTE, Richard P, METT, Igor, AKOPIAN, Violetta, KALINSKI, Hagar, MINOMI, Kenjiro
• Format: Patent
• Language: Danish
• Published: 08.10.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.