Optimerede antistoffer rettet mod CD19

The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg³R or alters effector function as compared to the parent antibody. Also disclosed are methods of us...

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Main Authors Bernett, Matthew J, Richards, John O, Zhukovsky, Eugene Alexander, KARKI, Sher Bahadur, Lazar, Gregory Alan, Pong, Erik WeiKing, Desjarlais, John R, Chu, Seung Yup
Format Patent
LanguageDanish
Published 04.07.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Abstract The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg³R or alters effector function as compared to the parent antibody. Also disclosed are methods of using said antibodies.
AbstractList The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg³R or alters effector function as compared to the parent antibody. Also disclosed are methods of using said antibodies.
Author Pong, Erik WeiKing
Richards, John O
Desjarlais, John R
KARKI, Sher Bahadur
Lazar, Gregory Alan
Zhukovsky, Eugene Alexander
Bernett, Matthew J
Chu, Seung Yup
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– fullname: Zhukovsky, Eugene Alexander
– fullname: KARKI, Sher Bahadur
– fullname: Lazar, Gregory Alan
– fullname: Pong, Erik WeiKing
– fullname: Desjarlais, John R
– fullname: Chu, Seung Yup
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Snippet The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein...
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SubjectTerms BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
Title Optimerede antistoffer rettet mod CD19
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