Genetiske forandringer af isocitratdehydrogenase og andre gener i ondartet gliom

• Main Authors: VOGELSTEIN, Bert, KINZLER, Kenneth W, BIGNER, Darell, ZHANG, Xiaosong, RIGGINS, Gregory J, LIN, Jimmy Cheng-Ho, VELCULESCU, Victor, PAPADOPOULOS, Nickolas, ANGENENDT, Philipp, JONES, Sian, KUAN, Chien-Tsun, LEARY, Rebecca J, PARSONS, D. Williams, YAN, Hai, PARMIGIANI, Giovanni, KARCHIN, Rachel
• Format: Patent
• Language: Danish
• Published: 16.01.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R17...