Improving sleep or controlling sleep disorders

• Main Authors: DAELE, GEORGES VAN, VLAEMINCK, FREDDY FRANCOIS, VERDONCK, MARC GUSTAAF CELINE
• Format: Patent
• Language: Danish; English
• Published: 19.07.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The use of a piperazine alkanamide of formula (I) in the mfr. of a medicament for improving sleep or treating sleep disorders is new: R1 = H or alkyl; X = alkyl (opt. substd. by OH, alkoxy, NH2CO (opt. mono- or di-substd. by alkyl), COOH, or alkoxycarbonyl), NH2CO (opt. mono- or di-substd. by alkyl or mono-substd. by hydroxyalkyl), COOH or alkoxycarbonyl; m = 1 or 2; R2 = H or alkyl; Ar = (a) phenyl (opt. substd. by 1-3 of OH, alkyl, alkoxy, halo, CF3, alkylcarbonyl, NH2CO (opt. mono- or di-susbtd. by alkyl), alkoxycarbonyl, NO2, CN, NH2 (opt. mono- or di-substd. by alkyl, or mono-substd. by alkylcarbonyl or NH2CO), NH2CH2 or PhCH2O; (b) pyridinyl (opt. substd. by 1-3 of halo and alkyl); (c) pyrazolyl (opt. substd. by 1-3 of halo and alkyl); or (d) a gp. of formula (II): R3, R4 = halo, alkyl, OH or alkoxy; s = 3, 4 or 5; Alk = 1-6C alkylene (opt. substd. by OH or alkyl) or 3-6C alkenylene; Q = aryl, aryloxy, diarylmethoxy, 2,2-diarylethenyl, diarylmethylcarbonyl, arylcarbonyl, mono- or diarylaminocarbonyl, diarylmethyl, or arylamino (in which the amino moiety is opt. substd. by aryl, arylcarbonyl, alkylcarbonyl, arylsulphonyl or alkylsulphonyl); in which ''aryl'' is phenyl (opt. mono- or disubstd. by halo or alkoxy) naphthalenyl, thienyl or pyridyl. All alkyl gps. and moieties contain 1-6C. Certain cpds. (I) are claimed as new.