ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF EN BASISK ETHER ELLER ET FARMACEUTISK ACCEPTABELT SYREADDITIONSSALT ELLER KVATERNAERT SALT DERAF

• Main Authors: LASZLO MAGDANYI, TIBOR MEZEI, ZOLTAN BUDAI, KATALIN GRASSER, LUJZA PETOECZ, IBOLYA KOSOCZKY, ARANKA LAY
• Format: Patent
• Language: Danish
• Published: 09.10.1989
• Edition: 4
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salts thereof, /I/ wherein R1 and R2 may be the same or different and represent a C1-5 alkyl group or a C3-6 cycloalkyl group or they form, together with the adjacent nitrogen atom, a heterocyclic ring containing 4-7 carbon atoms and optionally a further hetero atom, e.g. an oxygen, sulfur or nitrogen atom, and this latter may be optionally substituted by a C1-3 alkyl, benzyl or phenyl group, R represents a phenyl, phenyl-/C1-3 alkyl/ or thienyl group optionally substituted by one or more halogen or C1-3 alkoxy substituent/s/, A represents a C2-5 straight or branched alkylene chain, and represents a valence bond of alpha or beta configuration. The new compounds of the general formula /I/ possess valuable anticonvulsive, motility inhibiting, hexobarbital narcose potentiating and analgesic effects, which are, in case of certain compounds, complemented by week antiserotonine, gastro-intestinal-tract inhibiting and antiinflammatory effects, and can be applied to advantage in the therapy.