Fremgangsmåde til sammenlignende gennemsøgning af stoffer med farmakologisk virkning

• Main Authors: WEYER-CZERNILOFSKY, ULRIKE, LOEBER, GERHARD, VON RUEDEN, THOMAS, TONTSCH, ULRIKE, SCHNITZER, RENATE, WICHE-CASTANON, MARIA, JOSEFA, CZERNILOFSKY, ARMIN, PETER, METZ, THOMAS, STRATOWA, CHRISTIAN, HIMMLER, ADOLF, SPEVAK, WALTER
• Format: Patent
• Language: Danish
• Published: 01.12.2003
• Edition: 7
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention concerns a method of comparative high-throughput screening of pharmacologically active substances. In one process step the substances are deposited on test cells that contain one or more biological target molecules, the cells having an identical biological base composition and differing in their target molecules, and/or are deposited on cells having a different biological base composition and identical target molecules. The effect of the substance on the activity of the target molecules is measured using a detection system linked to the activation of the target molecule and is compared directly with the effect on other molecules.