Nanoemulsion von dem Öl-in-Wasser Typ, gebrauchbar als ein ophthalmischen Vehikel und Verfahren zur seiner Herstellung
The nanoemulsion comprises: 0.1-10% (w/v) of an oil; 0.1-10% (w/v) of a non-ionic surface active agent; a maximum of 0.01% (w/v) of benzalkonium chloride; a drug or a precursor or active substance; and optionally, one or several of the following components: an isotonizing agent, a viscosity modifyin...
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Main Authors | , , |
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Format | Patent |
Language | German |
Published |
15.04.2004
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | The nanoemulsion comprises: 0.1-10% (w/v) of an oil; 0.1-10% (w/v) of a non-ionic surface active agent; a maximum of 0.01% (w/v) of benzalkonium chloride; a drug or a precursor or active substance; and optionally, one or several of the following components: an isotonizing agent, a viscosity modifying agent or stabilizer, a buffer and/or an antioxidant in variable proportions. The process comprises: (a) preparing an aqueous phase containing, among others, a non-ionic surface active agent; (b) preparing an organic phase containing dissolved an oil and an active substance in an organic water miscible solvent in all proportions; (c) including the organic phase to the aqueous phase under moderate agitation; and (d) totally evaporating the organic solvent and part of the water up to the final desired volume. Important applications as an ophthalmic vehicle in preparations used to treat eye disorders and diseases. |
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Bibliography: | Application Number: DE19956031179T |