Neue reaktive Thiophosphat-Derivate von Thia(dia)zol-Essigsäure und Verfahren zur Herstellung derselben

• Main Authors: LIM, JONG CHAN, YOUSEONG-KU, DAEJEON, KR, KWON, TAE SUK, YOUSEONG-KU, DAEJEON, KR, KIM, WOO HYUN, SEO-KU, DAEJEON, KR, KIM, SUNG KYUM, YOUSEONG-KU, DAEJEON, KR, PARK, BONG JUN, YOUSEONG-KU, DAEJEON, KR
• Format: Patent
• Language: German
• Published: 29.10.1998
• Edition: 6
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to a novel reactive thiophosphate derivative of thia(dia)zole acetic acid which can be very effectively used in preparation of beta -lactam antibiotics and represented by the following general formula (I): in which R represents hydrogen or an amino-protecting group; R represents hydrogen, C1-C4 alkyl or -C(R)(R)CO2R, wherein R and R in the group -C(R)(R)CO2R for R are identical or different from each other and represent hydrogen or C1-C4 alkyl or R and R together with a carbon atom to which they are bound can form a C3-C7 cycloalkyl group and R is hydrogen or a carboxy-protecting group; R represents C1-C4 alkyl or phenyl or R together with an oxygen atom and a phosphorus atom to which it is bound can form a 5- or 6-membered heterocyclic ring; and Q represents N or CH, and to a process for preparing the same.d