Verfahren zur Herstellung von 3-Exomethylencephamsulfoxidestern

• Main Authors: COPP, JAMES DENSMORE, ROCKVILLE, INDIANA 47872, US, THARP, GREGG ALAN, TERRE HAUTE, INDIANA 47803, US
• Format: Patent
• Language: German
• Published: 12.03.1998
• Edition: 6
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

3-Exomethylenecepham sulfoxide esters are obtained in improved yields via cyclization of 3-methyl-2-(4-chlorosulfinyl-2-oxo-3-acylamino-1-azetidinyl)-3-butenoic acid esters under anhydrous conditions with stannic chloride in the presence of both an oxo compound, e.g., an ether such as diethyl ether,...