ZUSAMMENSETZUNG FUER DAS AUSBESSERN VON KNORPEL UND KNOCHEN UND VERFAHREN FUER IHRE ZUBEREITUNG ALS SKELETT-GEWEBE-IMPLANTAT

• Main Author: ITAY, SAMUEL., KFAR SABA, IL
• Format: Patent
• Language: German
• Published: 05.08.1993
• Edition: 5
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

A composition for the regeneration of articular cartilage and bones by implantation comprising cells expressing a chondrocyte phenotype (80 x 10 cells/ml), namely bone marrow derived chondrocytes or osteoblasts of autologous or homologous origin, or homologous committed chondrocytes, or autologous or homologous muscle fibroblast derived chondrocytes or any other progenital cells from mesenchymal origin, which are embedded in a biodegradable, biocompatible, biological resorbable immobilization vehicle (BRIV) adhesive glue consisting of fibrinogen, thrombin, CaCl2, protease inhibitor, and at least 10%, preferably 15-30%, serum, and a process for the preparation of such composition as skeletal tissue implant. A portion of the implant may comprise a bone segment or a bone substitute.