NEUE GUANIDIN-DERIVATE ALS ZELLADHÄSION-INHIBITOREN

• Main Authors: GOURVEST, JEAN-FRANCOIS, CARNIATO, DENIS, GADEK, THOMAS, WILL, WILLIAM, KNOLLE, JOCHEN, BODARY, CATHERINE, SCHEUNEMANN, KARL-HEINZ, PEYMAN, ANUSCHIRWAN
• Format: Patent
• Language: German
• Published: 25.08.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to acylguanidine derivatives of the formula I, in which R , R , R , Ar, X and n have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the formula I are valuable pharmacologically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and inhibit bone resorption by osteoclasts. They are suitable, for example, for the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example osteoporosis. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.