New 3'-derivatised oligo:nucleotide analogues
3'-Derivatised oligonucleotide analogues of formula (I) and (II) and their salts are new: R -(A )n'-(B )m'-(A )n-(B )m-B (I); R -(A )n'-(B )m'-(A )n-A (II); A and A = gps. of formula (i); B and B = gps. of formula (ii); B = a gp. of formula (iii); and A = a gp. of formula (i...
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Main Authors | , , |
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Format | Patent |
Language | English German |
Published |
11.01.1996
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Abstract | 3'-Derivatised oligonucleotide analogues of formula (I) and (II) and their salts are new: R -(A )n'-(B )m'-(A )n-(B )m-B (I); R -(A )n'-(B )m'-(A )n-A (II); A and A = gps. of formula (i); B and B = gps. of formula (ii); B = a gp. of formula (iii); and A = a gp. of formula (iv); a and b = 0 to 20; R = H, 1-18C alkyl, 2-18C alkenyl, 3-18C alkynyl, 2-19C alkanoyl, 3-20C alkenoyl, 4-20C alkynoyl, 6-20C aryl, (6-14C)aryl(1-8C)alkyl or P(W)ZZ'; R = H, OH, 1-18C alkoxy, halogen, azido or NH2; D = OH or OPO3<2->; B = a natural or unnatural nucleotide base; n = 1-100; n' = 0-50; m = 0-5; m' = 0-5 in (I) or 1-5 in (II); A = O, S or CH2; W = O, S or Se; V = O or S; T = O, S or NH; Y = O, S, NH or CH2; X = OH or SH; U = OH, SH, BH3 (sic), SeH, 1-18C alkoxy, 1-18C alkyl, 6-20C aryl, (6-14C)aryl(1-8C)alkyl, NHR , NR R or (OCH2CH2)pO(CH2)qCH2R ; R = 1-18C alkyl, 6-20C aryl, (6-14C)aryl(1-8C)alkyl or (CH2)c(NH(CH2)c)dNR R ; c = 2-6; d = 0-6; R = H, 1-6C alkyl or (1-4C)alkoxy(1-6C)alkyl; R = 1-18C alkyl, 6-20C aryl or (6-14C)aryl(1-8C)alkyl; or NR R = a 5- or 6-membered ring opt. contg. another N, O or S atom; p = 1-100; q = 0-22; R = H or a functional gp. such as OH, NH2, NHR , COOH, CONH2, COOR or halogen; R = 1-6C alkyl, R = 1-4C alkyl; Z and Z' = OH, SH, SeH, 1-22C alkoxy, O(CH2)bNHR 'R ', 1-18C alkyl, 6-20C aryl, (6-14)aryl(1-8C)alkyl (where aryl includes heteroaryl and is opt. substd. by 1-3 of COOH, NH2, NO2, 1-4C alkylamino, 1-6C alkoxy, OH, halogen and CN), 1-18C alkylthio, NHR , NR R , a 3'- or 5'-linked nucleoside or oligonucleotide, or a gp. which enhances intracellular uptake, serves as a DNA probe label or binds to, crosslinks with or cleaves a target nucleic acid after hybridisation; R 'R ' = as R , R ; or NR 'R = a 3- to 6-membered ring. |
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AbstractList | 3'-Derivatised oligonucleotide analogues of formula (I) and (II) and their salts are new: R -(A )n'-(B )m'-(A )n-(B )m-B (I); R -(A )n'-(B )m'-(A )n-A (II); A and A = gps. of formula (i); B and B = gps. of formula (ii); B = a gp. of formula (iii); and A = a gp. of formula (iv); a and b = 0 to 20; R = H, 1-18C alkyl, 2-18C alkenyl, 3-18C alkynyl, 2-19C alkanoyl, 3-20C alkenoyl, 4-20C alkynoyl, 6-20C aryl, (6-14C)aryl(1-8C)alkyl or P(W)ZZ'; R = H, OH, 1-18C alkoxy, halogen, azido or NH2; D = OH or OPO3<2->; B = a natural or unnatural nucleotide base; n = 1-100; n' = 0-50; m = 0-5; m' = 0-5 in (I) or 1-5 in (II); A = O, S or CH2; W = O, S or Se; V = O or S; T = O, S or NH; Y = O, S, NH or CH2; X = OH or SH; U = OH, SH, BH3 (sic), SeH, 1-18C alkoxy, 1-18C alkyl, 6-20C aryl, (6-14C)aryl(1-8C)alkyl, NHR , NR R or (OCH2CH2)pO(CH2)qCH2R ; R = 1-18C alkyl, 6-20C aryl, (6-14C)aryl(1-8C)alkyl or (CH2)c(NH(CH2)c)dNR R ; c = 2-6; d = 0-6; R = H, 1-6C alkyl or (1-4C)alkoxy(1-6C)alkyl; R = 1-18C alkyl, 6-20C aryl or (6-14C)aryl(1-8C)alkyl; or NR R = a 5- or 6-membered ring opt. contg. another N, O or S atom; p = 1-100; q = 0-22; R = H or a functional gp. such as OH, NH2, NHR , COOH, CONH2, COOR or halogen; R = 1-6C alkyl, R = 1-4C alkyl; Z and Z' = OH, SH, SeH, 1-22C alkoxy, O(CH2)bNHR 'R ', 1-18C alkyl, 6-20C aryl, (6-14)aryl(1-8C)alkyl (where aryl includes heteroaryl and is opt. substd. by 1-3 of COOH, NH2, NO2, 1-4C alkylamino, 1-6C alkoxy, OH, halogen and CN), 1-18C alkylthio, NHR , NR R , a 3'- or 5'-linked nucleoside or oligonucleotide, or a gp. which enhances intracellular uptake, serves as a DNA probe label or binds to, crosslinks with or cleaves a target nucleic acid after hybridisation; R 'R ' = as R , R ; or NR 'R = a 3- to 6-membered ring. |
Author | PEYMAN, ANUSCHIRWAN., 65779 KELKHEIM, DE CAROLUS, CAROLIN, 65321 FRANKFURT, DE UHLMANN, EUGEN., 61479 GLASHUETTEN, DE |
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DocumentTitleAlternate | Neue 3'-Modifizierte Oligonucleotid-Derivate |
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Snippet | 3'-Derivatised oligonucleotide analogues of formula (I) and (II) and their salts are new: R -(A )n'-(B )m'-(A )n-(B )m-B (I); R -(A )n'-(B )m'-(A )n-A (II); A... |
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SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SUGARS VINEGAR WINE |
Title | New 3'-derivatised oligo:nucleotide analogues |
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