Verfahren zur Herstellung von D,L-Carnitinamidchlorid

1. Process for the preparation of D,L-carnitinamide chloride (I) see diagramm : EP0166901,P3,F1 characterized in that, in a first reaction stage, 2,3-epoxypropyltrimethylammonium chloride is reacted in aqueous solution with 0.8 to 2.0 equivalents of hydrocyanic acid at a pH above 7 and not above 11...

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Bibliographic Details
Main Author KLENK, HERBERT. DR., 6450 HANAU, DE
Format Patent
LanguageGerman
Published 14.08.1985
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:1. Process for the preparation of D,L-carnitinamide chloride (I) see diagramm : EP0166901,P3,F1 characterized in that, in a first reaction stage, 2,3-epoxypropyltrimethylammonium chloride is reacted in aqueous solution with 0.8 to 2.0 equivalents of hydrocyanic acid at a pH above 7 and not above 11 and at a temperature between 20 and 100 degrees C, and the resulting nitrile is, without intermediate isolation and without addition of base, treated in the reaction solution with 1.5 to 5 equivalents of aqueous hydrogen peroxide at a temperature between 30 and 100 degrees C, and the reaction product is isolated in a manner known per se.
Bibliography:Application Number: DE19843420391