OXYTOCIN-ANALOGA, IHRE HERSTELLUNG UND PHARMAZEUTISCHE MITTEL

Analogs of oxytocin of general formula I where all amino acids are L-isomers and X is phenylalanine or phenylalanine substituted in the p-position by alkyl, ethoxy, amino, substituted amino, or nitro group, suitable for medical applications, and a method for their preparation consisting in the cycli...

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Main Authors HRBAS,PAVEL,DR, BARTH,TOMISLAV,DR, SKOPKOVA,JANA,DR, LEBL,MICHAL, MACHOVA,ALENA,DR, SLANINOVA,JIRINA,DR, JOST,KAREL,DR
Format Patent
LanguageGerman
Published 08.04.1982
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Analogs of oxytocin of general formula I where all amino acids are L-isomers and X is phenylalanine or phenylalanine substituted in the p-position by alkyl, ethoxy, amino, substituted amino, or nitro group, suitable for medical applications, and a method for their preparation consisting in the cyclization of linear octapeptides of general formula II where X has the aforesaid meaning and Act is a group activating the carboxylic group of S-carboxyethylhomocysteine residue, e.g. an active ester. Two methods may be used for the preparation of [2-p-aminophenylalanine] deamino-6-carba-oxytocin, either the reduction of [2-p-nitrophenylalanine]- deamino-6-carba-oxytocin or deprotection of [2-p- benzyloxycarbonylaminophenylalanine] deamino-6-carba-oxytocin.
Bibliography:Application Number: DE19813124818