Anti-{alpha}iv{beta}i3 recombinant antibodies, functional fragments thereof, nucleic acid molecules encoding thereof and use of such antibodies

• Main Authors: WU HERREN, HUSE WILLIAM D
• Format: Patent
• Language: Czech; English
• Published: 01.12.2010
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Rešení se týká protilátky s implantovaným zesíleným LM609 mající zesílenou selektivní vazebnou aktivitu .alfa..sub.V.n..beta..sub.3.n., nebo její funkcní fragment. Rovnež poskytuje molekuly nukleové kyseliny kódující protilátku s implantovaným zesíleným LM609. Dále poskytuje zpusoby inhibice funkce .alfa..sub.V.n..beta..sub.3 .n.kontaktem .alfa..sub.V.n..beta..sub.3 .n.s protilátkou s implantovaným zesíleným LM609. The present invention relates to enhanced LM609 grafted antibodies exhibiting selective binding affinity to {alpha}iv{beta}i3, or a functional fragment thereof. The invention also provides nucleic acid molecules encoding the enhanced LM609 grafted antibodies. Additionally provided are methods of inhibiting a function of {alpha}iv{beta}i3 recombinant antibodies by contacting {alpha}iv{beta}i3 recombinant antibodies with an enhanced LM609 grafted antibody.