ΚΡΥΣΤΑΛΛΟΙ ΒΙΚΑΛΟΥΤΑΜΙΔΗΣ ΚΑΙ ΜΕΘΟΔΟΣ ΠΑΡΑΓΩΓΗΣ ΤΟΥΣ

• Main Authors: ITAYA NOBUSHIGE, KATSURA TADASHI, SHINTAKU TETSUYA
• Format: Patent
• Language: Greek
• Published: 29.04.2015
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Η παρούσα εφεύρεση σχετίζεται με ένα κρύσταλλο βικαλουταμίδης η οποία έχει μια ορισμένη μορφή, καθώς επίσης και με οικονομικές και βιομηχανικώς πρακτικές μεθόδους παραγωγής βικαλουταμίδης και ενός κρυστάλλου αυτής, οι οποίες είναι ανώτερες ως προς την ηπιότητα έναντι του περιβάλλοντος και την ασφάλεια. The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. Accordingly, the present invention provides a production method of bicalutamide represented by the formula (I): which includes at least a step of reacting a compound represented by the formula (3): with an oxidizing agent, a production method of a crystal of bicalutamide, as well as a crystal form of bicalutamide as defined by X-ray diffraction (XRD) or solid C NMR measurement.