DERIVADOS DE HETEROARILO COMO MODULADORES DE NACHR ALFA 7

• Main Authors: HAJARE, ANIL KASHIRAM, SINHA, NEELIMA, TILEKAR, AJAY RAMCHANDRA, KAMBOJ, RAJENDER KUMAR, SACHCHIDANAND, SACHCHIDANAND, KARCHE, NAVNATH POPAT, JANA, GOURHARI, PALLE, VENKATA P, KURHADE, SANJAY PRALHAD
• Format: Patent
• Language: Spanish
• Published: 25.04.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Se divulga un compuesto de la fórmula (I), en donde Z, m y R1 -R6 se describen en la misma, como un modulador de receptores de acetilcolina nicotínica particularmente del subtipo alfa 7, en un sujeto en necesidad del mismo, para su uso ya sea solos o en combinaciones con otros medicamentos adecuados, y composiciones farmacéuticas que contienen dichos compuestos. También se divulgan un proceso de preparación de los compuestos y sus usos pretendidos en terapia, particularmente en la profilaxis y terapia de trastornos tales como la enfermedad de Alzheimer, deterioro cognitivo leve, demencia senil, y similares. Disclosed is a compound of formula I: wherein Z, m and R1-R6 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the α7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.