COMPUESTOS DERIVADOS DE TRIAZOL/ISOXAZOL-METOXINAFTIRIDINA SUSTITUIDOS Y PIRIDO[3,4-C]PIRIDAZINA ÚTILES PARA EL TRATAMIENTO DE ENFERMEDADES RELACIONADAS CON EL RECEPTOR GABA a5

• Main Authors: Kapus, Gábor László, Szabó, György, Potor, Attila, Túrós, György István, Éliás, Olivér, Vágó, István
• Format: Patent
• Language: Spanish
• Published: 11.05.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La presente invención proporciona compuestos de Ia fórmula (I) ESPACIO PARA FÓRMULA , que tienen afinidad y selectividad por el receptor A subunidad α5 del ácido γ-aminobutírico (GABAA α5) y actúan como moduladores alostéricos positivos GABAA α5 ( GABAA α5 PAM), útiles en el tratamiento o Ia prevención de enfermedades relacionadas con el receptor GABAA α5. The present invention provides compounds of formula (I) and/or salts thereof and/or biologically active metabolites thereof and/or prodrugs thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA α5 positive allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA α5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.