PROCESS FOR PREPARING DERIVATIVES OF 3-/HYDROXYMETHYL/-ISOQUINOLINE

• Main Authors: LING ISTVAN,HU, ELEK SANDOR DR.,HU, ELEKES ISTVAN DR.,HU, BOTKA PETER,HU, LANG ZSUZSANNA DR.,HU, HAMORI TAMAS,HU, ZOLYOMI GABOR DR.,HU, VARRO ANDRAS DR.,HU, SAROSSY JUDIT,HU, KOROSI JENO DR.,HU, LANG TIBOR DR.,HU, MORAVCSIK IMRE,HU, RABLOCZKY GYORGY DR.,HU
• Format: Patent
• Language: English
• Published: 13.06.1989
• Edition: 4
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to new 3-(hydroxymethyl)-isoquinoline derivatives of the general formula (I), their acid addition salts, and to a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same, (I) wherein R and R1 are identical or different and stand for a hydrogen or halogen atom, a nitro or a C1-4 alkoxy group, R2 stands for a hydrogen atom or a C1-4 alkyl group, R3 and R4 are identical or different and stand for a hydrogen atom or a C1-4 alkyl group, or R3 and R4 combined denote a methylene group, with the proviso that when R stands for 3-methoxy, R1 for 4-methoxy, R3 and R4 are identical and represent methyl or ethyl groups, R2 is other than hydrogen atom. The compounds of the general formula (I) exert valuable positive inotropic (cardiotonic) potency, they are capable to increase the myocardiac contractile force (heart performance in cardiac insufficiency), thus they can be applied in the therapy of chronic heart failure and coronary ailments.