Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio

• Main Authors: BUSCHMANN, Helmut, HAWE, Andrea, REDMER, Jessica, CERON BERTRAN, Jordi Carles, GOLDNER, Thomas, ROSA, Monica, LUCKE, Matthias, HOHMANN, Dorothea
• Format: Patent
• Language: Spanish
• Published: 08.11.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La presente invención se refiere a nuevas composiciones farmacéuticas estables que contienen ácido 2-[(4S)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4H-quinazolin-4-il] acético e iones de sodio que están esencialmente libres de agentes solubilizantes formadores de complejos, tales como PEG, ciclodextrina, lisina, arginina, en particular HPBCD. La invención se refiere además a métodos de preparación de dichas composiciones farmacéuticas. La invención se refiere además al uso de dichas composiciones farmacéuticas en métodos de tratamiento y/o como profiláctico de enfermedades, particularmente su uso como un antivírico, preferentemente contra citomegalovirus. The present invention relates to new stable pharmaceutical compositions containing 2-[(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid and sodium ions that are essentially free from complexing solubilizing agents, such as PEG, cyclodextrin, lysine, arginine, in particular HPBCD. The invention further relates to methods of preparation of said pharmaceutical compositions. The invention further relates to use of said pharmaceutical compositions in methods of treatment of and/or as a prophylactic for illnesses, particularly its use as an antiviral, preferably against cytomegaloviruses.