4,5-dihydro-imidazole as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion ch...

Full description

Saved in:
Bibliographic Details
Main Author SHUM PATRICK,GROSS ALEXANDRE,MA LIANG,MCGARRY DANIEL G.,MERRIMAN GREGORY H.,RAMPE DAVID,RINGHEIM GARTH,SABOL JEFFREY STEPHEN,VOLZ FRANCIS A
Format Patent
LanguageEnglish
Published 30.08.2006
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer's disease, etc.
Bibliography:Application Number: CN200480020830