Novel synthesis technology of N-methyl-2-methyl-3-thia-5-chlorovaleryl amine

• Main Authors: JINQING HAN, YUANAN JIA, YIMIN MA
• Format: Patent
• Language: Chinese; English
• Published: 22.12.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

A process for synthesizing N-methyl-2-methyl-3-thia-5-chloropentylamide includes such steps as heating chloropropionate to 50-60 deg.C, adding methanol solution of methylamine, reaction for 1-2 hr, distilling to removing methanol, adding methanol solution of sodium carboxyl ethoxide, reaction at 50-60 deg.C for 2 hr, filtering out sodium chloride, distilling out methanol, adding trichloromethane, dripping sulfoxide chloride, and reaction for 2 hr. N-甲基-2-甲基-3-硫杂-5-氯戊酰胺的一种合成工艺，其特征是包括以下步骤：1.将氯丙酸酯加热到50-60℃，加一甲胺甲醇溶液，反应1-2小时，蒸出溶剂甲醇；2.加入巯基乙醇钠的甲醇溶液，在50-60℃反应2小时，然后过滤出去氯化钠，蒸出溶剂甲醇；3.加入三氯甲烷，在温度0-5℃下滴加氯化亚砜，室温反应2小时；本发明减去了加固体氢氧化钠的麻烦，温度易控制，反应平稳，目标化合物不易分解，收率高，产品含量达到95％以上，有利其高含量衍生物的生成；并且减少原料消耗，节约了能源，降低了成本。