Process for preparing chiral (S)-2, 3-disubstituted-1-propylamine derivatives

• Main Authors: ROH KYOUNG ROK, LEE JUNG HWAN, HWANG DAE IL
• Format: Patent
• Language: English
• Published: 27.06.2001
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

A process for the preparation of chiral (S)-2,3-disubstituted-1-propylamine derivatives, in which a carbonyl group of (S) 3,4-disubstituted-1-butanecarbonyl derivatives is converted to an amine group, and the conversion reaction is performed through Curtius rearrangement or Hoffman rearrangement.