Open-loop resin glycoside derivative as well as preparation method and application thereof

• Main Authors: WANG WENLI, GUO SUPENG, LAN XIN, GU HONG, FAN BOYI, GUO JIA
• Format: Patent
• Language: Chinese; English
• Published: 25.04.2025
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention belongs to the technical field of medicines, and discloses a ring-opened resin glycoside derivative as well as a preparation method and application thereof. According to the method disclosed by the invention, the ring-opening resin glycoside derivative with a novel chemical structure is obtained by taking a sedge tricolor seed as a separation target and comprehensively applying a plurality of separation technologies and means. In-vitro activity experiments prove that the ring-opened resin glycoside derivative provided by the invention has remarkable anti-neuroinflammation activity, can be used as an active ingredient for treating neuroinflammation related diseases, and has wide application. 本发明属于医药技术领域，公开了一种开环树脂糖苷类衍生物及其制备方法与应用。本发明以三色旋花种子为分离目标，综合运用多种分离技术和手段，得到具有新颖的化学结构的开环树脂糖苷类衍生物。通过体外活性实验证实，本发明提供的开环树脂糖苷类衍生物具有显著的抗神经炎症活性，可以作为治疗神经炎症相关疾病的活性成分，具有广泛的用途。