Tetrahydrofuroylamide compound as sodium channel regulator and application of tetrahydrofuroylamide compound in medicine

• Main Authors: ZHU XIAOYUN, JIANG WEIPING
• Format: Patent
• Language: Chinese; English
• Published: 10.01.2025
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an N-(hydroxyalkyl pyridyl) tetrahydrofuran carboxamide compound, a prodrug, an oxide, a salt, a metal complex or a stereochemical isomer of a sodium channel regulator and a pharmaceutical composition containing the N-(hydroxyalkyl pyridyl) tetrahydrofuran carboxamide compound, the prodrug, the oxide, the salt, the metal complex or the stereochemical isomer. And their use as Nav inhibitors and their use in the preparation of medicaments for the treatment and/or alleviation of pain and pain-related diseases. The compound provided by the invention has the advantages of high metabolic stability, high oral absorption, better bioavailability, better activity, higher selectivity, better pharmacokinetic property, quicker effect, low cardiac side effect and the like. 本发明提供了一种钠通道调节剂的N-（羟烷基吡啶基）四氢呋喃甲酰胺类化合物、前药、氧化物、盐、金属络合物或立体化学异构体和含有其的药物组合物，以及其作为Nav抑制剂的用途和其在制备治疗和/或减轻感痛和疼痛相关疾病的药物中的用途。本发明提供的化合物具有代谢稳定性高、口服吸收高、更优的生物利用度、活性更好，选择性更高，药代动力学性质更佳，起效更快、心脏副作用低等优点。