Marker for olfactory neuroblastoma subtype classification and application thereof

• Main Authors: YU HONGMENG, SONG XIAOLE, YANG JINGYI, SHI JUNFENG, SUN XICAI, ZHOU CHENGLE
• Format: Patent
• Language: Chinese; English
• Published: 13.12.2024
• Subjects: BEER; BIOCHEMISTRY; CALCULATING; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPUTING; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; COUNTING; ELECTRIC DIGITAL DATA PROCESSING; ENZYMOLOGY; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention relates to the field of disease diagnosis, and particularly discloses a marker for olfactory neuroblastoma subtype classification, and the marker comprises a substrate type marker, a nerve type marker and a mesenchymal type marker. The typing gene expression profile used in the invention is derived from high-precision single cell sequencing, has high accuracy and distinction degree, and can be projected to ordinary transcriptome sequencing with relatively simple sequencing steps and low cost to obtain a typing conclusion, so that verification and popularization within a certain range are facilitated, and the method has a wide application prospect. The kit is helpful for typing ONB patients in clinical work, and assists corresponding drug treatment selection according to molecular characteristics of each subtype. 本申请涉及疾病诊断领域，具体公开了一种用于嗅神经母细胞瘤亚型分类的标志物，所述标志物包括基底型标志物、神经型标志物和间充质型标志物。本申请所使用的分型基因表达谱来源于高精度的单细胞测序，具有较高的准确性及区分度，且可以投射到测序步骤相对简单、成本较低的普通转录组测序中得出分型结论，因此有利于在一定范围内验证并推广，有助于临床工作中对ONB患者进行分型，并根据各亚型分子特