Medicine, combination medicine, pharmaceutical composition, immune response cell, nucleic acid delivery medium and product for treating cancer

• Main Authors: SAKODA YUKIMI, TAMADA KOJI, ADACHI KEISHI
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An exemplary combination medicine of the present disclosure is useful for treating cancer in a subject, comprising: (a1) an immune response cell expressing a cell surface molecule that specifically recognizes a cancer antigen, interleukin 7, and CCL19 or (a2) in cooperation with one or more cells or a nucleic acid delivery medium comprising a nucleic acid encoding interleukin 7 and a nucleic acid encoding CCL19, or a combination thereof; and (b) an immunosuppressive blocking agent. Exemplary immune responsive cells of the present disclosure express a cell surface molecule that specifically recognizes a cancer antigen, interleukin 7, CCL19, and an immunosuppressive blocking polypeptide. 本公开的示例性组合医药用于治疗对象中的癌症，包含：(a1)表达特异性识别癌抗原的细胞表面分子、白细胞介素7和CCL19的免疫应答细胞或者(a2)协同包含编码白细胞介素7的核酸以及编码CCL19的核酸的一种或多种细胞或者核酸递送介质或者它们的组合；以及(b)免疫抑制阻断剂。本公开的示例性免疫应答细胞对特异性识别癌抗原的细胞表面分子、白细胞介素7、CCL19、以及免疫抑制阻断性多肽进行表达。