Compounds and methods for targeting interleukin 34

• Main Authors: SCOLA, ANDREW, DAVID, MINTHONG MILIND, WEST ERIC ANTHONY, LOO ALEXANDER, SIMS, JOHN, R., II, WALSH, RICHARD, E, CHEAD MICHAEL, FLEISCHER AMY S, RANNAN MANISH BABU, RAINES, SCOTT, E, OBUNGU VICTOR H, YE, MING
• Format: Patent
• Language: Chinese; English
• Published: 20.08.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present disclosure relates to IL-34 antibodies, compositions comprising the antibodies, and methods of using the antibodies and or compositions thereof for the treatment of immune-mediated diseases, such as neurodegenerative diseases, such as Alzheimer's disease or tauopathy. 本公开涉及IL-34抗体、包含该抗体的组合物以及使用该抗体和或其组合物用于治疗免疫介导的疾病例如神经退行性疾病，例如阿尔茨海默氏病或tau蛋白病的方法。