Liquid chromatography-mass spectrometry detection method for improving chromatographic behavior of oligonucleotide drug

• Main Authors: LU JINLIAN, AN PEIYUN, XING LILI, SHEN LIANG, WU XIAOPENG, TAO YI
• Format: Patent
• Language: Chinese; English
• Published: 19.07.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a liquid chromatography-mass spectrometry detection method for improving the chromatographic behavior of an oligonucleotide drug, a pretreatment solution is added in the pretreatment process, a sample is pretreated by combining solid-phase extraction and other pretreatment st...