Acetylcholine receptor inhibitory peptides and uses thereof

• Main Authors: KIM SUNG-HYUN, SHIN YONGUL, KIM JIN-HWA, YUN YEONG-SEONG, CHOI WON-IL, LEE JEUNG-HOON
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention relates to an acetylcholine receptor inhibitory peptide and application thereof, bacteriophage with high binding force to an acetylcholine receptor is screened out by using random peptide recombinant bacteriophage, and acetylcholine receptor binding peptide is screened out through DNA (deoxyribonucleic acid) of the bacteriophage. Binding force to acetylcholine receptors and inhibitory effect of acetylcholine receptors have been confirmed by using selected peptides, and peptide sites and sequences that are important for binding to acetylcholine receptors have been confirmed by modifying the peptides, whereby it is expected that the acetylcholine receptors have been inhibited by using the acetylcholine receptor inhibitory peptides of the present invention. Thus, a cosmetic composition for improving wrinkles, a drug for preventing or treating acetylcholine receptor-related diseases, and a health functional food can be developed. 本发明涉及一种乙酰胆碱受体抑制肽及其用途，利用随机肽重组噬菌体筛选出对乙酰胆碱受体具有高结合力的噬菌体，并通过噬菌体的DNA筛选出乙酰胆碱受