MiRNA and disease association prediction method and device, electronic equipment and storage medium

• Main Authors: QIN KAILIN, HU YULAN, ZHANG CHUNHUI
• Format: Patent
• Language: Chinese; English
• Published: 09.07.2024
• Subjects: CALCULATING; COMPUTER SYSTEMS BASED ON SPECIFIC COMPUTATIONAL MODELS; COMPUTING; COUNTING; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

The invention discloses a miRNA and disease association prediction method and device, electronic equipment and a storage medium. The association prediction method comprises the following steps: acquiring initial association data of miRNA and a disease; calculating miRNA similarity and disease similarity based on the initial associated data; based on the miRNA similarity and the disease similarity, a dynamic hypergraph is constructed, and the dynamic hypergraph comprises a first node feature of the miRNA, a first node feature of the disease, a hyperedge connected with the first node feature of the miRNA and a hyperedge connected with the first node feature of the disease; obtaining a second node feature of the miRNA and a second node feature of the disease based on the dynamic hypergraph; and obtaining an association prediction result of the miRNA and the disease based on the second node feature of the miRNA and the second node feature of the disease. According to the prediction method, the hypergraph structur