Three-side-wall molecular cup macrocyclic host compound based on derivatization of resorcinol calix [4] arene and preparation method and application of three-side-wall molecular cup macrocyclic host compound

• Main Authors: YI XIAOWEN, YU YANG, ZHU YUJIE
• Format: Patent
• Language: Chinese; English
• Published: 09.07.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of supramolecular chemical macrocyclic subject design and subject-object recognition, in particular to a three-side-wall molecular cup macrocyclic subject compound based on resorcinol calix [4] arene derivatization as well as a preparation method and application of the three-side-wall molecular cup macrocyclic subject compound. The synthesis method comprises the following steps: by taking retorlocked phenol calix [4] arene as a framework, retaining two phenolic hydroxyl groups, and sequentially deepening three aromatic walls and introducing upper edge 2, 1, 3-benzoselenadiazole and lower edge water-soluble groups, thereby realizing the synthesis of a water-soluble three-side wall 2, 1, 3-benzoselenadiazole molecular cup main body H1. Compared with the prior art, the method has the advantages of simple process route, easily available raw materials, high yield and good repeatability. The cavity structure of the molecular cup main body H1 has a larger cavity due to lack of a wa