Preparation of modified cold water fish skin gelatin tissue adhesive

• Main Authors: JI QIAN, CHEN XI, JIA CHUNING
• Format: Patent
• Language: Chinese; English
• Published: 28.05.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention discloses preparation of a modified cold water fish skin gelatin tissue adhesive, and belongs to the technical field of biological materials. The method mainly comprises the following steps: (1) carrying out polyphenol group structure modification on FSGltn molecules to prepare modified cold water fish skin gelatin; (2) carrying out oxidation ring opening on polysaccharide to form dialdehyde, and crosslinking the modified cold water fish skin gelatin into a tissue adhesive through Schiff base reaction by taking polysaccharide dialdehyde as a crosslinking agent; and (3) the tissue adhesive with excellent ductility and tissue adhesion in a humid environment is constructed. The modified cold water fish skin gelatin and the polysaccharide dialdehyde are mixed in a double-tube injection mode, and can be quickly gelatinized within 20s. The cross-linked and formed tissue adhesive has no obvious mass loss after being soaked in a PBS (Phosphate Buffer Solution) for more than 80 hours; the tissue adhesive