Application of core proteoglycan combined with NK (Natural Killer) cells in treatment of solid tumors

• Main Authors: MAO ZHUANG, WANG JINGYI, YANG YUEFENG, LIU WEI, HAN RUISHENG, LI XUE, HUANG YUANYUAN, WANG DI, WANG LIYAN
• Format: Patent
• Language: Chinese; English
• Published: 17.05.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of core proteoglycan combined with NK (Natural Killer) cells in treatment of solid tumors, through treatment of combined drugs, growth of tumor cells can be remarkably inhibited, the number of NK cells in peripheral blood of a subject can be increased, the activity of the NK cells in the peripheral blood can be promoted, the expression level of perforin and interferon in the body of the subject can be improved, and the treatment effect of the core proteoglycan combined with the NK cells can be improved. The anti-tumor capability is improved. The pharmaceutical composition provided by the invention has wide application prospects in cancers, especially solid tumors. 本发明公开了核心蛋白聚糖联合NK细胞在治疗实体瘤中的应用，经过本发明的联合药物治疗，可显著抑制肿瘤细胞生长，增强受试者外周血中的NK细胞数量，促进外周血中NK细胞的活性，提高了受试者体内穿孔素和干扰素的表达水平，提高了抗肿瘤能力。本发明所提供的药物组合物及应用在癌症尤其是实体瘤中的应用前景广泛。