Synthesis method of chloride intermediate in epoxiconazole synthesis

• Main Authors: WANG JIN, ZENG TING, TONG YUANYUAN, PAN GUANGFEI, WU CHENXING, LIAO WENBIN, HE MENGKAI, QI FEI, GUO JUN
• Format: Patent
• Language: Chinese; English
• Published: 10.05.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a method for synthesizing a chloride intermediate in epoxiconazole synthesis, which comprises the following steps: in the presence of a catalyst and a solvent a, adding sulfonyl chloride into an olefin intermediate for reaction to obtain the chloride intermediate, the olefin intermediate is # imgabs0 #, and the content of the olefin intermediate is 96%; the mass ratio of the olefin intermediate to the solvent a to the catalyst to the sulfonyl chloride is (150-180): (100-120): (2.5-4): (79-95.1); according to the synthesis method of the chloride intermediate in epoxiconazole synthesis, 6-chloropurine and tetrabutylammonium bromide are adopted as catalysts, so that the selectivity of the generated target chloride intermediate can be improved in the synthesis process, the content of the target chloride intermediate is improved, and the yield of the chloride intermediate in epoxiconazole synthesis is greatly improved. 本发明公开了一种氟环唑合成中氯化物中间体的合成方法，包括在催化剂和溶剂a存在的条件下，在烯烃中间体中加入磺酰氯进行反应，得到氯化物中间体，其中，