Recombinant subunit vaccine aiming at RSV and application thereof
The invention belongs to the field of biological medicine, particularly relates to a recombinant subunit vaccine aiming at a respiratory syncytial virus (RSV) and application of the recombinant subunit vaccine, and more particularly relates to a recombinant fusion protein containing a Head only (RHF...
Saved in:
Main Authors | , , , , , , , , , , , , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
07.05.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The invention belongs to the field of biological medicine, particularly relates to a recombinant subunit vaccine aiming at a respiratory syncytial virus (RSV) and application of the recombinant subunit vaccine, and more particularly relates to a recombinant fusion protein containing a Head only (RHF) structural domain and a multimerization structural domain of an RSV envelope fusion protein F, such as an immunoglobulin Fc fragment, an expression construct containing the recombinant fusion protein, and an application of the recombinant subunit vaccine. The present invention relates to recombinant fusion proteins, methods of making the recombinant fusion proteins, and immunogenic compositions, such as vaccines, comprising the recombinant fusion proteins.
本发明属于生物医药领域,具体涉及一种针对呼吸道合胞病毒(Respiratory syncytial virus,RSV)的重组亚单位疫苗及其应用,更具体涉及包含RSV包膜融合蛋白F的Head only(RHF)结构域和多聚化结构域例如免疫球蛋白Fc片段的重组融合蛋白,包含所述重组融合蛋白的表达构建体,所述重组融合蛋白的制备方法,以及包括该重组融合蛋白的免疫原性组合物,例如疫苗。 |
---|---|
AbstractList | The invention belongs to the field of biological medicine, particularly relates to a recombinant subunit vaccine aiming at a respiratory syncytial virus (RSV) and application of the recombinant subunit vaccine, and more particularly relates to a recombinant fusion protein containing a Head only (RHF) structural domain and a multimerization structural domain of an RSV envelope fusion protein F, such as an immunoglobulin Fc fragment, an expression construct containing the recombinant fusion protein, and an application of the recombinant subunit vaccine. The present invention relates to recombinant fusion proteins, methods of making the recombinant fusion proteins, and immunogenic compositions, such as vaccines, comprising the recombinant fusion proteins.
本发明属于生物医药领域,具体涉及一种针对呼吸道合胞病毒(Respiratory syncytial virus,RSV)的重组亚单位疫苗及其应用,更具体涉及包含RSV包膜融合蛋白F的Head only(RHF)结构域和多聚化结构域例如免疫球蛋白Fc片段的重组融合蛋白,包含所述重组融合蛋白的表达构建体,所述重组融合蛋白的制备方法,以及包括该重组融合蛋白的免疫原性组合物,例如疫苗。 |
Author | CHEN JUNNA WANG YAN HUANG PEIXIN JIANG XULIN LIU YONGJIANG JIANG DUNQUAN JIANG PING GAO JUN ZHANG YAO YANG XIUFEN YIN YAJIE SHEN ERCUI ZHANG SHIBIN LIU YUYING ZHANG HUAN YIN FEI |
Author_xml | – fullname: GAO JUN – fullname: JIANG DUNQUAN – fullname: YIN FEI – fullname: ZHANG HUAN – fullname: JIANG XULIN – fullname: CHEN JUNNA – fullname: JIANG PING – fullname: LIU YUYING – fullname: YANG XIUFEN – fullname: HUANG PEIXIN – fullname: ZHANG YAO – fullname: YIN YAJIE – fullname: SHEN ERCUI – fullname: LIU YONGJIANG – fullname: ZHANG SHIBIN – fullname: WANG YAN |
BookMark | eNqNyj0OglAMAOA36ODfHeoBHJBEcSRE4-SAxpWUWrQJtC--4vldPIDTt3zzMFFTnoWyZrKhFUV1SGM7qjh8kEiUAWUQfQI61Nc7oD4AY-yF0MUU_MVvtm4Zph32iVc_F2F9Ot6q84ajNZwiEit7U12ybH8odnmxLfN_zhcIVzNO |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
DocumentTitleAlternate | 针对RSV的重组亚单位疫苗及其应用 |
ExternalDocumentID | CN117986382A |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_CN117986382A3 |
IEDL.DBID | EVB |
IngestDate | Fri Aug 02 08:54:06 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | Chinese English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_CN117986382A3 |
Notes | Application Number: CN202311207094 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240507&DB=EPODOC&CC=CN&NR=117986382A |
ParticipantIDs | epo_espacenet_CN117986382A |
PublicationCentury | 2000 |
PublicationDate | 20240507 |
PublicationDateYYYYMMDD | 2024-05-07 |
PublicationDate_xml | – month: 05 year: 2024 text: 20240507 day: 07 |
PublicationDecade | 2020 |
PublicationYear | 2024 |
RelatedCompanies | BEIJING HEALTH GUARD BIOTECHNOLOGY CO., LTD |
RelatedCompanies_xml | – name: BEIJING HEALTH GUARD BIOTECHNOLOGY CO., LTD |
Score | 3.6742713 |
Snippet | The invention belongs to the field of biological medicine, particularly relates to a recombinant subunit vaccine aiming at a respiratory syncytial virus (RSV)... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
Title | Recombinant subunit vaccine aiming at RSV and application thereof |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240507&DB=EPODOC&locale=&CC=CN&NR=117986382A |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1dS8Mw8JhT1Dedis4PIkjfiuv6FR-KbOnGEOzGnGNvI2nTqWA7bKfgr_cSNrcXfQtJOC7HXe6S-wK4aXDbkiL2TO9O2qaTCsekqDXNxE1pUzYSZBodIBt5vWfnYeJOKvC2yoXRdUK_dHFElKgY5b3U9_V8_YkV6tjK4la84lR-3x0FobF8HaN6QvvGCNtBZ9AP-8xgLGCREQ0DVfmMIq81W1uwrcxoVWe_M26rrJT5pkrpHsDOAKFl5SFUvl9qsMdWnddqsPu4dHjjcCl7xRG01EvxXejIFVIsxAKFkXzyWG0kXDXnmhFekuHTmPAsIRueaaKMPJmnx3Dd7YxYz0Rcpr8Hn7JojbZ9AtUsz-QpEItzTrnr-7bnOw3uU0smaLjY1OUxjVPrDOp_w6n_t3gO-4qIOqDPv4Bq-bGQl6h0S3GlqfUDFyCGIA |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1dT8Iw8IJoxDdFjeJXTczeFhn7qg-LgQ6CCoMgEt5It3V-JA7ihib-eq8NCC_61rTNpb3c9e56XwBXVW4aIowc3bkRpm4loaVTlJp6bCe0JqoxEo0KkA2c9pN1P7bHBXhb5sKoOqFfqjgiclSE_J6r93q2-sTyVWxldh2-4tT0tjX0fG1hHaN4Qv1G8xtes9_ze0xjzGOBFgw8WfmMIq3V6huw6aJJqEylUUNmpczWRUprF7b6CC3N96Dw_VKGElt2XivDdnfh8MbhgveyfahLS_E9VJErJJuHc2RG8skjuZFw2ZzrmfCcDB5HhKcxWfNME6nkiWlyAJet5pC1dTzL5PfiExasjm0eQjGdpuIIiME5p9x2XdNxrSp3qSFiVFxMavOIRolxDJW_4VT-W7yAUnvY7Uw6d8HDCexIhKrgPvcUivnHXJyhAM7Dc4W5H4GmiQo |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Recombinant+subunit+vaccine+aiming+at+RSV+and+application+thereof&rft.inventor=GAO+JUN&rft.inventor=JIANG+DUNQUAN&rft.inventor=YIN+FEI&rft.inventor=ZHANG+HUAN&rft.inventor=JIANG+XULIN&rft.inventor=CHEN+JUNNA&rft.inventor=JIANG+PING&rft.inventor=LIU+YUYING&rft.inventor=YANG+XIUFEN&rft.inventor=HUANG+PEIXIN&rft.inventor=ZHANG+YAO&rft.inventor=YIN+YAJIE&rft.inventor=SHEN+ERCUI&rft.inventor=LIU+YONGJIANG&rft.inventor=ZHANG+SHIBIN&rft.inventor=WANG+YAN&rft.date=2024-05-07&rft.externalDBID=A&rft.externalDocID=CN117986382A |