Recombinant subunit vaccine aiming at RSV and application thereof

• Main Authors: GAO JUN, JIANG DUNQUAN, YIN FEI, ZHANG HUAN, JIANG XULIN, CHEN JUNNA, JIANG PING, LIU YUYING, YANG XIUFEN, HUANG PEIXIN, ZHANG YAO, YIN YAJIE, SHEN ERCUI, LIU YONGJIANG, ZHANG SHIBIN, WANG YAN
• Format: Patent
• Language: Chinese; English
• Published: 07.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention belongs to the field of biological medicine, particularly relates to a recombinant subunit vaccine aiming at a respiratory syncytial virus (RSV) and application of the recombinant subunit vaccine, and more particularly relates to a recombinant fusion protein containing a Head only (RHF) structural domain and a multimerization structural domain of an RSV envelope fusion protein F, such as an immunoglobulin Fc fragment, an expression construct containing the recombinant fusion protein, and an application of the recombinant subunit vaccine. The present invention relates to recombinant fusion proteins, methods of making the recombinant fusion proteins, and immunogenic compositions, such as vaccines, comprising the recombinant fusion proteins. 本发明属于生物医药领域，具体涉及一种针对呼吸道合胞病毒(Respiratory syncytial virus，RSV)的重组亚单位疫苗及其应用，更具体涉及包含RSV包膜融合蛋白F的Head only(RHF)结构域和多聚化结构域例如免疫球蛋白Fc片段的重组融合蛋白，包含所述重组融合蛋白的表达构建体，所述重组融合蛋白的制备方法，以及包括该重组融合蛋白的免疫原性组合物，例如疫苗。