Supramolecular hybrid hydrogel capable of continuously removing hydroxyl radicals and preparation method of supramolecular hybrid hydrogel

• Main Authors: GAO ZIQIAN, ZHANG YING, ZHANG TING, LIU DONGPING, JIAO SONGYAN
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; GENERAL PROCESSES OF COMPOUNDING; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

The invention discloses supramolecular hybrid hydrogel capable of continuously removing hydroxyl radicals and a preparation method of the supramolecular hybrid hydrogel. The multifunctional injectable supramolecular hybrid hydrogel (HCPA) is synthesized by personalized design, natural hyaluronic acid modified beta-cyclodextrin (HA-CD) is used as a subject, adamantane modified polypyrrole (PPy-Ad) connected by phenylboronic acid dynamic covalent bonds is used as an object, and in-situ synthesis is performed under the action of the subject and the object. The HCPA supramolecular hybrid hydrogel has the comprehensive properties of proper morphology, excellent rheological property, ROS and pH dual responsiveness, oxidation resistance, conductivity, drug controlled release and the like, and can be used as a potential drug or cell carrier for treating diseases such as myocardial infarction, diabetic wounds and the like. 本发明公开了一种可持续清除羟基自由基的超分子杂化水凝胶及其制备方法。本发明个性化设计合成了一种多功能可注射超分子杂化水凝胶(HCPA)，利用天然透明质酸修饰β-环糊精(HA-CD)作为主体，苯