MRNA vaccine and application thereof

• Main Authors: ZHANG HONGHAO, GUO JIAXIN, LI YUHUA, CEN QINGYAN, HU YUXING, CHEN JIANYU
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an mRNA (messenger Ribonucleic Acid) vaccine and application thereof, the mRNA vaccine comprises one or more mRNA molecules, and the mRNA molecules encode a CXC chemokine ligand 16 (CXCL16), a glucocorticoid induced TNF (Tumor Necrosis Factor) receptor ligand (GITRL) or a cell surface chemokine receptor 7 (CCR7). The mRNA vaccine can simultaneously promote DC cell homing, activate anti-tumor immune cells, promote in-tumor infiltration of the immune cells and improve an inhibitory immune microenvironment, so that the anti-tumor immune effect of T cells is exerted to the maximum extent. 本发明公开了一种mRNA疫苗及其应用，该mRNA疫苗包含一种或多种mRNA分子，所述mRNA分子编码CXC趋化因子配体16(CXCL16)、糖皮质激素诱导的TNF受体配体(GITRL)或细胞表面趋化因子受体7(CCR7)。本发明mRNA疫苗可同时促进DC细胞归巢、激活抗肿瘤免疫细胞、促进免疫细胞肿瘤内浸润及改善抑制性免疫微环境，从而最大程度发挥T细胞的抗肿瘤免疫效应。