Key intermediate of 4-acetyl-2-methyl benzoic acid and synthesis method thereof

• Main Authors: ZHENG XINGXING, HUANG WENFEI, YUAN XUESONG, LIU XIANJUN, YU FEIFEI, YANG SHANGYAN
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of synthesis of medicine agricultural intermediates, and particularly relates to a key intermediate of 4-acetyl-2-methyl benzoic acid and a synthesis method of the key intermediate. The invention provides a novel compound V and a synthesis method thereof, and provides a method for synthesizing a compound I by using the novel compound V. The method comprises the following steps: reacting a compound II with bromine to obtain a compound III; reacting the compound III with thionyl chloride and heating to obtain a compound IV; reacting the compound IV with dimethyl malonate under the action of alkali to obtain a new compound V; hydrolyzing the compound V under the action of concentrated hydrochloric acid to obtain a compound VI; reacting the compound VI with cuprous cyanide under the action of a catalyst to obtain a compound VII; the compound VII is hydrolyzed into a compound I under the action of strong base. The synthesis route is simple, the process selection is reas